I've used Greenshot ("cinst greenshot" using Chocolatey) almost daily since I installed it. It inserts itself as a workflow process tool for acting on screenshots. Rarely would anyone just take a screenshot and save it, but rather there's probably some action needed.
With Greenshot, you press the PrintScreen button and drag a box around what you want, and then choose an option from the menu. It supports plugins including Imgur and Dropbox which I use frequently.
Also the "Open in image editor" option lets you add annotations and blur out text.
Check out this tool!